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KMID : 0387820080150020075
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Clinical Pediatric Hematology-Oncology
2008 Volume.15 No. 2 p.75 ~ p.82
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Vancomycin-resistant Enterococci Colonization of Pediatric Hematology and Oncology Patients
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Lee Seong-Wook
Park Jun-Eun
Jung Hyun-Joo
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Abstract
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Purpose: Vancomycin-resistant enterococci (VRE) are significantly increased as nosocomial pathogens in immunocompromised patients. But the identification of risk factors for VRE colonization and the guideline for management of VRE colonization are necessary for children’s hematology and oncology wards.
Methods: Eleven cases of VRE intestinal colonizations occurred at a children’s tertiary cancer hospital between 1 January 2004 and 31 December 2007. We reviewed medical records of cases retrospectively and performed a matched case-control study to identify risk factors of the VRE colonization.
Results: All 11 VRE colonizations were due to Enterococcus faecium vanA and seasonal outbreak occurred in winter. Univariate analysis identified the hospital admission duration associated with VRE colonization (P=0.048). The prolonged course of antimicrobial therapys promoted VRE colonizations (P=0.006). Despite no specific antibiotics therapy just for VRE colonizations, spontaneous negative conversions occurred in 3 cases and there were no evidences of the VRE infection.
Conclusion: It’s reasonable to withhold the VRE eradication provided surveillance and hygienic controls are strictly applied.
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KEYWORD
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Vancomycin-resistant, Enterococci, Hematological malignancies, Rectal colonization
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